摘要 :
Objective: Less than 15% of adults in the USA over age 70 receive hearing screening;less than 20% of adults with hearing loss receive any form of treatment. Reasons vary, but affordability and accessibility are major barriers to i...
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Objective: Less than 15% of adults in the USA over age 70 receive hearing screening;less than 20% of adults with hearing loss receive any form of treatment. Reasons vary, but affordability and accessibility are major barriers to intervention and treatment. This study provides data supporting a new adult hearing screening measure (NSRT) that is self-administered, easy to use and focused on difficulties experienced in everyday speech communication. Methods: The NSRT test materials are sentence-length utterances containing phonetic contrasts. The test requires respondents to determine whether sentences printed on a computer monitor are the same/different from sentences delivered as auditory stimuli through the computer sound card. The test is administered in quiet and +5 dB SNR background noise. Study participants were 120 adults aged 18 - 88 years. Results: Data obtained from the NSRT testing experience are used to construct a pseudo audiogram. When the predicted hearing thresholds were compared with conventional, clinical puretone measures, the sensitivity and specificity of the NSRT screening measure were 95% and 87%, respectively;diagnostic accuracy was 91%. Conclusions: The NSRT can identify individuals with hearing loss through a simple screening process grounded in standards set by the American Speech-Language-Hearing Association. The NSRT is suitable for administration in clinical and nonclinical settings.
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摘要 :
Aim: This study was carried out to assess association between Sensorineural hearing loss (SNHL) and Chronic Suppurative Otitis Media (CSOM), to identify possible risk factors and determine correlation of duration of CSOM and incid...
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Aim: This study was carried out to assess association between Sensorineural hearing loss (SNHL) and Chronic Suppurative Otitis Media (CSOM), to identify possible risk factors and determine correlation of duration of CSOM and incidence of SNHL. Material and Method: The study consisted of 100 patients of either sex between 15 and 40 years of age, suffering from unilateral CSOM for the past three months or more, the normal ear served as control. Results: This study showed duration of symptoms is 18% patients for 5 - 10 years and below 5 years in 73% patients. It was found that mean BC thresholds were significantly higher in the diseased ears as compared to the control ears. Though the higher frequencies are more affected than the lower frequencies, in subtotal and attic perforations the speech frequencies seemed to be maximally affected. Conclusion: CSOM should be diagnosed early and should be managed effectively so as to prevent the chances of developing SNHL.
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摘要 :
The inflammasome is a multiprotein oligomer in the cell cytoplasm and is part of the innate immune system.It plays a crucial role in the pathological process of noise-induced hearing loss(NIHL).However,the mechanisms of NLR family...
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The inflammasome is a multiprotein oligomer in the cell cytoplasm and is part of the innate immune system.It plays a crucial role in the pathological process of noise-induced hearing loss(NIHL).However,the mechanisms of NLR family pyrin domain containing 3(NLRP3)inflammasome activation in NIHL have not been clearly demonstrated.In this study,miniature pigs were exposed to white noise at 120 dB(A)and auditory brainstem response measurements were used to measure their hearing function.Immunofluorescence staining,confocal laser scanning microscopy,western blot assay,and quantitative reverse transcription-polymerase chain reaction were used to analyze inflammasome-related protein distribution and expression.NLRP3,interleukin-1β,interleukin-18,and cleaved-caspase-1 were highly expressed in the cochlea after 120 dB(A)white noise exposure.Our findings suggest that NLRP3-inflammasomes in the cochlea may be activated after acoustic trauma,which may be an important mechanism of noise-induced hearing loss.
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